Posted September 18, 2026 at 8:20 AM ET

Buffalo opened its new Highmark Stadium with a 41-31 rout of Detroit on Thursday night, but the headline for fantasy managers isn’t Josh Allen‘s five touchdown passes — it’s DJ Moore walking to the locker room with a shoulder injury in the second quarter. The good news arrived Friday morning. Beyond Buffalo, Friday is also the day the league’s crowded Week 2 questionable tier gets its final practice before designations lock in, so this roundup rolls up everything that moved on Thursday for players who haven’t had their status refreshed on an indexed post yet.

Status At a Glance

Player	Team / Pos	Status	Fantasy Move
DJ Moore	BUF WR	🟡 Questionable (Wk 3)	Bench-and-hold; check Friday designations before Week 3 lineups
Michael Penix Jr.	ATL QB	🟡 Questionable	Superflex stash only; Atlanta hasn’t named a starter
Tua Tagovailoa	ATL QB	🔴 Trending out	Line up a streamer for Sunday against Carolina
Alvin Kamara	NO RB	🟢 Trending toward playing	Start as an RB2 if he practises again Friday
Kyler Murray	MIN QB	🟡 Questionable	Start a streamer; he still needs protocol clearance
Nico Collins	HOU WR	🟡 Questionable	Have Kayshon Boutte ready if Collins has no Friday practice
Zay Flowers	BAL WR	🔴 Trending out	Start Rashod Bateman unless Flowers practises Friday
Ladd McConkey	LAC WR	🟡 Questionable	Start Quentin Johnston; McConkey needs a Friday session
RJ Harvey	DEN RB	🟡 Questionable	Keep a healthy flex ready until Friday’s designation
Marvin Mims Jr.	DEN WR	🔴 Trending out	Bench Mims; start a healthy receiver Sunday
Chig Okonkwo	WAS TE	🔴 Trending out	Stream a tight end against Dallas
Ty Johnson	BUF RB	🔴 Out	Leave on waivers; Buffalo’s backfield needs no reinforcement

🟢 Likely or trending toward playing · 🟡 Questionable or genuinely uncertain · 🔴 Out or trending out. A Questionable tag carries very different odds depending on how a player practised the day before — don’t treat every yellow the same.

Wide Receivers

🟡 Questionable (Week 3) — DJ Moore (Bills): Moore went down hard in the end zone chasing a Josh Allen pass late in the second quarter, grabbing the left side of his collarbone before walking to the locker room under his own power. He didn’t return, and the Bills initially had no update beyond “shoulder and stinger.” Friday morning brought the real news: X-rays ruled out a fracture, and NFL Network’s Ian Rapoport reported the diagnosis as an AC joint sprain, with ESPN’s Adam Schefter adding that doctors don’t consider it serious and that Moore is day-to-day. The timing helps — Buffalo doesn’t play again for ten days — but both insiders stopped short of calling a Week 3 start against the Chargers a lock. Fantasy Action: hold Moore in every format and treat him as a bench-and-monitor case rather than a drop; re-check his practice participation once Buffalo’s next injury report opens next week.

🟡 Questionable — Nico Collins (Texans): Collins strained his hamstring at Wednesday’s practice and sat out entirely on Thursday, missing both of Houston’s Week 2 sessions so far. The Houston Chronicle’s Aaron Wilson has it as a Grade 1 strain, the mildest grade, but a hamstring that costs a player back-to-back practices still trends toward missed time more often than not. Fantasy Action: have Kayshon Boutte ready to start in Collins’s place if Friday brings another absence, and hold Collins in every format regardless.

🔴 Trending out — Zay Flowers (Ravens): Flowers missed both of Baltimore’s Week 2 practices on the hamstring he re-aggravated during his 150-yard day at Indianapolis. NFL Media’s Ian Rapoport has said he would have played in a playoff game, but two straight misses on a re-pulled hamstring leaves only Friday to reach even a Questionable tag. Fantasy Action: start Rashod Bateman in Flowers’s spot and check Friday’s practice report before finalizing your Sunday lineup.

🟡 Questionable — Ladd McConkey (Chargers): McConkey worked on the side field again Thursday, a second straight missed practice on the rib injury that Jim Harbaugh has called day-to-day after clean imaging. Only Friday is left before the Chargers host Las Vegas. Fantasy Action: start Quentin Johnston, who is the Chargers’ clear No. 2 receiver whether or not McConkey plays, and revisit McConkey if he practises Friday.

🔴 Trending out — Marvin Mims Jr. (Broncos): Mims sat out Thursday’s observed session for the second straight day with the foot injury he carried through the opener, while backfield-mate RJ Harvey upgraded alongside him. Denver sets its final designations Friday ahead of hosting Jacksonville. Fantasy Action: bench Mims and start a healthy receiver unless Friday brings a full practice.

Quarterbacks

🟡 Questionable — Michael Penix Jr. (Falcons): Penix split first-team reps with Cooper Rush again on Thursday as Tua Tagovailoa sat out a second straight day with his oblique, and Atlanta still hasn’t named a Week 2 starter. Fantasy Action: hold Penix as a superflex stash and do not start him blind until Atlanta commits to a starter.

🔴 Trending out — Tua Tagovailoa (Falcons): Tagovailoa missed his second straight practice Thursday with the oblique he aggravated in a throwing drill, and an oblique re-aggravated by throwing rarely clears in one final session. Fantasy Action: line up a streaming quarterback for Sunday against Carolina and hold Tua rather than dropping him.

🟡 Questionable — Kyler Murray (Vikings): Murray was limited for a second straight day at Thursday’s practice as he works through the concussion protocol he entered after a late hit from Green Bay’s Javon Bullard in Week 1. NFL Network’s Ian Rapoport says he has a chance to play at Chicago, but an independent neurological consultant still has to sign off, which makes Friday the real deadline. Fantasy Action: hold Murray everywhere but start a streaming quarterback against Chicago until he’s actually cleared.

Running Backs

🟢 Trending toward playing — Alvin Kamara (Saints): Kamara practised in full on Wednesday for the first time since his Grade 2 MCL sprain and was inactive at Detroit in Week 1. Kellen Moore said afterward that New Orleans feels good about him playing Baltimore this week. Fantasy Action: start Kamara as an RB2 if he strings together a Friday practice, and slide Travis Etienne Jr. back to your flex.

🟡 Questionable — RJ Harvey (Broncos): Harvey upgraded from a non-participant to limited at Thursday’s practice on his hamstring, the first sign of real progress since Monday night’s game. Denver sets Friday designations before hosting Jacksonville. Fantasy Action: keep Harvey rostered and flex him only if Friday brings a full practice; keep a healthy replacement warm either way.

🔴 Out — Ty Johnson (Bills): Johnson was inactive Thursday night against Detroit after Buffalo listed him Questionable on the hamstring that has now cost him two straight games. Frank Gore Jr. remains the backup behind Buffalo’s committee, but the team hasn’t needed him yet. Fantasy Action: leave Johnson on waivers; revisit only if he strings full Week 3 practices together.

Tight Ends

🔴 Trending out — Chig Okonkwo (Commanders): Okonkwo has now missed both of Washington’s Week 2 practices with the hamstring that ended his Commanders debut early, and only Friday is left before Sunday’s game against Dallas. The Athletic’s Nicki Jhabvala reports John Bates would lead the Commanders’ tight end room if Okonkwo can’t go. Fantasy Action: line up a streaming tight end now and hold Okonkwo on your bench rather than dropping him.

Every one of these Friday practice reports feeds straight into the full Week 2 injury report, which updates as soon as final designations land this afternoon.

Sources

• NFL.com: Bills WR DJ Moore ruled out Thursday vs. Lions with shoulder injury
• ESPN: Bills rule out D.J. Moore after WR suffers shoulder injury
• Buffalo Bills official site: Bills issue injury update on WR DJ Moore
• SI.com (Bills On SI): DJ Moore injury update confirms Bills’ WR avoided serious issue
• Yahoo Sports: Bills suffer major injury in warmups before Lions Thursday night game
• ClickOnDetroit: Detroit Lions injury report: 6 players out, 1 questionable for Thursday Night Football game vs. Bills