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James Cook III Injury Update
RB · Buffalo Bills · Status, injury history and fantasy outlook
Updated · synced from the live injury report
Current status
HEALTHY
No current injury designation
Latest
James Cook III’s current injury designation is shown in the live status box above, which updates automatically from the official NFL injury report. He started all 17 games in 2025 and has no injury designations this season in the reports we checked.
Cook led the NFL with 1,621 rushing yards in 2025, then ran 34 times for 192 yards and a touchdown in Buffalo’s first two games of 2026, per Pro Football Reference.
Fantasy Action: Start Cook as an RB1 every week he is active. Buffalo’s backup backs mainly handle change-of-pace and third-down work, leaving his early-down workload intact.
Injury timeline — 2026
| Nov 3 | Added to Buffalo’s injury report Questionable ahead of the Week 9 Monday-night game at Minnesota. |
Earlier seasons
| Season | Injury | Games missed |
|---|---|---|
| — | No prior-season injuries found in our sources. | — |
Started all 17 games in 2025 and led the NFL with 1,621 rushing yards on 309 carries with 12 rushing touchdowns, plus 33 catches for 291 yards and 2 scores, earning second-team All-Pro (Pro Football Reference).
Sources
James Cook III news
Frequently asked about James Cook III
Is James Cook III injured?
His current official designation is shown in the live status box at the top of this page, which updates automatically from the NFL injury report. He started all 17 games in 2025.
Does Ty Johnson’s return affect James Cook III?
Minimally. Johnson returned from a hamstring injury in late September as a third-down option, which mainly cuts into Ray Davis’ role.
Where he ranks this week
No injury designation
Bills starters
Ty Johnson (Questionable)RB
DJ Moore (Questionable)WR
Keon Coleman (Questionable)WR
Dalton Kincaid (Questionable)TE
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